Seroprevalence of NMO-IgG antibody in Brazilian patients with neuromyelitis optica.
نویسندگان
چکیده
OBJECTIVE To determine the seroprevalence of neuromyelitis optica antibody (NMO)-IgG in Brazilian patients with clinical diagnosis of relapsing neuromyelitis optica, also known as Devic's disease. METHOD We determined NMO-IgG titers in 28 patients (25 of them females) that fulfilled the 1999 NMO diagnostic criteria proposed by Wingerchuk et al. RESULTS NMO-IgG was detected in 18 NMO patients (64.3%). CONCLUSION Our results showed that seroprevalence of NMO-IgG in Brazilian NMO patients was similar to the observed in other studies.
منابع مشابه
Seroprevalence of NMO-IgG Antibody in Neuromyelitis optica (NMO) and Its Specificity in Differentiating NMO from Other Demyelinating Diseases with Overlap Symptoms: An Iranian Experience.
Neuromyelitis optica is an inflammatory demyelinating disease (IDD) of the CNS, which mainly affects optic nerve and spinal cord. Autoantibodies against aquaporin-4 also known as NMO-IgG have been implicated in the pathogenesis of NMO. We evaluated the sensitivity and specificity of NMO-IgG assay for diagnosing NMO patients and differentiating them from MS patients and those with undifferentiat...
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ورودعنوان ژورنال:
- Arquivos de neuro-psiquiatria
دوره 66 2B شماره
صفحات -
تاریخ انتشار 2008